منابع مشابه
The Hunger Genes: Pathways to Obesity
The global rise in the prevalence of obesity and associated co-morbidities such as type 2 diabetes, cardiovascular disease, and cancer represents a major public health concern. The biological response to increased consumption of palatable foods or a reduction in energy expenditure is highly variable between individuals. A more detailed mechanistic understanding of the molecular, physiological, ...
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Obesity is a major public health problem and an important risk factor for the development of chronic kidney disease (CKD). Several factors have been pointed to explain this association, but the exact mechanisms are not fully understood. In this work we focused on possible direct and indirect mechanisms underlying CKD development in obese patients. The need of potential interventions to lower CK...
متن کاملApoptosis: from Signalling Pathways to Therapeutic Tools
Apoptosis or programmed cell death is a gene regulated phenomenon which is important in both physiological and pathological conditions. It is characterized by distinct morphological features including chromatin condensation, cell and nuclear shrinkage, membrane blebbing and oligonucleosomal DNA fragmentation. Although, two major apoptotic pathways including 1) the death receptor (extrinsic) and...
متن کاملHypothalamic circuits regulating appetite and energy homeostasis: pathways to obesity
The 'obesity epidemic' represents a major global socioeconomic burden that urgently calls for a better understanding of the underlying causes of increased weight gain and its associated metabolic comorbidities, such as type 2 diabetes mellitus and cardiovascular diseases. Improving our understanding of the cellular basis of obesity could set the stage for the development of new therapeutic stra...
متن کاملNeurophysiological Pathways to Obesity: Below Awareness and Beyond Individual Control
A global obesity epidemic is occurring simultaneously with ongoing increases in the availability and salience of food in the environment. Obesity is increasing across all socioeconomic groups and educational levels and occurs even among individuals with the highest levels of education and expertise in nutrition and related fields. Given these circumstances, it is plausible that excessive food c...
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ژورنال
عنوان ژورنال: International Journal of Obesity
سال: 2002
ISSN: 0307-0565,1476-5497
DOI: 10.1038/sj.ijo.0802123